McCune-Albright syndrome (MAS) is a complex, multisystem disorder that may affect the bones, endocrine system, and skin. Because symptoms and severity can vary widely, treatment approaches are often tailored to each individual by medical professionals familiar with the condition.
This page outlines common categories of treatment for MAS, including medications, surgical procedures, and supportive therapies. All care decisions should be made in consultation with a qualified healthcare provider.
FD/MAS Toolkit
Explore the FD/MAS Toolkit for additional educational resources and care planning materials.
View the ToolkitMedication
Medical treatment for McCune-Albright syndrome typically focuses on managing endocrine-related symptoms. Medications may be used to regulate hormone overproduction and to address bone-related complications. These treatments are often part of a long-term management strategy developed by endocrinologists and other specialists.
Common areas of treatment may include:
- Cushing syndrome
- Hyperthyroidism
- Excess growth hormone
- Low blood phosphates
- Precocious puberty
- Bone pain or loss
Medication may also be prescribed to help mitigate pain or prevent bone damage, especially in cases involving polyostotic fibrous dysplasia.
Surgical Options
Surgical intervention may be considered in some cases of McCune-Albright syndrome, particularly when bone deformities or glandular issues are causing complications. These procedures aim to improve function, reduce pain, or prevent further damage.
Examples of potential surgeries include:
- Correction of uneven or deformed bone growth
- Removal of adrenal glands to address Cushing syndrome
- Thyroid gland removal for treatment-resistant hyperthyroidism
- Procedures to relieve nerve pressure affecting hearing or vision
Each surgical recommendation is typically based on the specific clinical presentation and severity of symptoms.
Supportive Therapies and Physical Strengthening
In addition to medication and surgery, physical therapy and strength-based exercise programs may offer additional benefits. Targeted exercise can help build muscle around weakened bone areas, which may improve mobility and reduce fracture risk. These approaches are commonly used in conjunction with medical or surgical treatment plans.
Treatment Planning and Ongoing Research
Because MAS can affect multiple body systems, there is no universal approach to care. Treatment typically evolves over time and may involve a combination of therapies. Ongoing research continues to explore new methods for improving outcomes and quality of life for individuals living with MAS.
FD/MAS Alliance is committed to sharing accurate, up-to-date information about treatment options and supporting continued progress in research and care.
Subscribe to the FD/MAS Newsletter
Stay informed: Sign up for the FD/MAS newsletter to receive updates, resources, and the latest news from the FD/MAS Alliance.